{"id":7719,"date":"2026-10-27T08:00:00","date_gmt":"2026-10-27T08:00:00","guid":{"rendered":"https:\/\/lipedemaac.com\/?p=7719"},"modified":"2026-10-15T10:34:24","modified_gmt":"2026-10-15T10:34:24","slug":"leg-pain-at-night","status":"publish","type":"post","link":"https:\/\/lipedemaac.com\/en\/leg-pain-at-night\/","title":{"rendered":"Leg pain at night: why your legs hurt at night and when to worry"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"7719\" class=\"elementor elementor-7719\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-90e672d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"90e672d\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-0a45790\" data-id=\"0a45790\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-2eea73a elementor-widget elementor-widget-html\" data-id=\"2eea73a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p>If your <b>legs hurt at night<\/b>, the explanation is almost always benign: the most common causes are <b>night leg cramps<\/b>, <b>restless legs syndrome<\/b> and the heaviness of <b>venous insufficiency<\/b>. But there is one kind of <b>leg pain at night<\/b> that should not be left until morning: a cold, pale foot that hurts at rest and feels better when you let the leg hang over the side of the bed.<\/p>\n\n<p>Here we explain how to tell each cause apart by <b>what it feels like, when it appears and what relieves it<\/b>, why &ldquo;put your legs up&rdquo; does not work for all of them and, before anything else, <b>which signs mean you need medical attention the same day<\/b>.<\/p>\n\n<h2><b>First, the signs that cannot wait<\/b><\/h2>\n\n<p>Most nights of leg pain are not an emergency. These are, or can be. <b>Call your local emergency number now (112 in Spain and the EU, 999 in the UK, 911 in the US) or go to the emergency department<\/b> if you notice:<\/p>\n\n<ul>\n<li><p><b>A foot or leg that suddenly turns cold, pale and painful<\/b>, within a matter of hours, with or without loss of strength or feeling: it may be an arterial embolism.<\/p><\/li>\n<li><p><b>Weakness, loss of strength or loss of feeling that comes on suddenly<\/b>, being unable to control your leg, difficulty walking, or loss of bladder or bowel control.<\/p><\/li>\n<li><p><b>Pain in a swollen leg together with chest pain, shortness of breath or coughing up blood<\/b>, or weakness with difficulty speaking, changes in vision or confusion.<\/p><\/li>\n<\/ul>\n\n<p><b>Get medical attention the same day<\/b> if you notice:<\/p>\n\n<ul>\n<li><p><b>Pain in your foot or leg that has been appearing at rest for weeks<\/b>, especially at night, and eases when you let the leg hang over the side of the bed, with a cold, pale or bluish foot: this points to an advanced lack of blood flow through the arteries.<\/p><\/li>\n<li><p><b>A wound on your foot or leg that will not heal<\/b>, especially if you have diabetes or smoke.<\/p><\/li>\n<li><p><b>A single leg that is swollen, warm, red and painful<\/b>: a deep vein thrombosis has to be ruled out.<\/p><\/li>\n<\/ul>\n\n<h3><b>When should I worry about leg pain at night?<\/b><\/h3>\n\n<p>Beyond the signs above, it is worth booking an appointment with your doctor in the next few days if the pain <b>wakes you up almost every night<\/b>, if it comes with <b>numbness or swelling<\/b>, if your cramps last longer than 10 minutes, or if pain appears when you walk and forces you to stop. None of these is an emergency on its own, but none of them is something to simply get used to either.<\/p>\n\n<h2><b>What kind of pain is it? A table to help you find your bearings<\/b><\/h2>\n\n<p>To make sense of night-time pain, whoever examines you will ask three things: <b>what it feels like<\/b>, <b>when it appears<\/b> and <b>what relieves it<\/b>. Those three answers separate the most common conditions fairly well.<\/p>\n\n<table>\n<thead>\n<tr><td><strong>Condition<\/strong><\/td><td><strong>What it feels like<\/strong><\/td><td><strong>When it appears<\/strong><\/td><td><strong>What relieves it<\/strong><\/td><td><strong>Clue that points to it<\/strong><\/td><\/tr>\n<\/thead>\n<tbody>\n<tr><td><p><b>Night leg cramp<\/b><\/p><\/td><td><p>Sudden, very painful contraction; the muscle feels hard<\/p><\/td><td><p>Wakes you abruptly; lasts from a few seconds to 10 minutes<\/p><\/td><td><p>Stretching the muscle or standing up with your weight on that leg<\/p><\/td><td><p>Almost always the calf; it can stay sore for up to 24 hours<\/p><\/td><\/tr>\n<tr><td><p><b>Restless legs<\/b><\/p><\/td><td><p>An urge to move your legs with an unpleasant sensation (tingling, pulling, burning)<\/p><\/td><td><p>When you sit or lie down; worse in the evening and at night<\/p><\/td><td><p>Moving or walking, for as long as the movement lasts<\/p><\/td><td><p>Family history; more common in women, in pregnancy and with iron deficiency<\/p><\/td><\/tr>\n<tr><td><p><b>Venous insufficiency<\/b><\/p><\/td><td><p>Heaviness, dull ache, sometimes cramps<\/p><\/td><td><p>Worse after many hours on your feet<\/p><\/td><td><p>Raising your legs and walking<\/p><\/td><td><p>Varicose veins, swelling, skin changes on the leg<\/p><\/td><\/tr>\n<tr><td><p><b>Artery disease with rest pain<\/b><\/p><\/td><td><p>Pain or burning in the foot and toes; even the weight of the bedsheet is bothersome<\/p><\/td><td><p>At night, lying down<\/p><\/td><td><p>Letting the leg hang over the side of the bed (raising it makes it worse)<\/p><\/td><td><p>Cold, pale or bluish foot; wounds that do not heal. Pain for weeks: <b>same day<\/b>. If the foot suddenly turns cold and pale: <b>emergency number<\/b><\/p><\/td><\/tr>\n<tr><td><p><b>Neuropathy<\/b><\/p><\/td><td><p>Burning, tingling, pins and needles, numbness<\/p><\/td><td><p>Noticed more at night<\/p><\/td><td><p>Depends on the cause<\/p><\/td><td><p>Starts in the toes and feet; diabetes is the most common cause<\/p><\/td><\/tr>\n<tr><td><p><b>Deep vein thrombosis<\/b><\/p><\/td><td><p>Pain or tenderness with swelling, warmth and redness<\/p><\/td><td><p>At any time, not only at night<\/p><\/td><td><p>Home measures do not resolve it<\/p><\/td><td><p>Almost always one leg only. <b>Same day<\/b><\/p><\/td><\/tr>\n<tr><td><p><b>Lipedema<\/b><\/p><\/td><td><p>Pain on pressure and touch, spontaneous pain, heaviness<\/p><\/td><td><p>Many patients describe a feeling of swelling that increases over the course of the day<\/p><\/td><td><p>Compression and movement during the day (S2k)<\/p><\/td><td><p>Symmetrical increase in fat in both legs, with the feet spared<\/p><\/td><\/tr>\n<tr><td><p><b>Growing pains<\/b><\/p><\/td><td><p>Pain or throbbing in both legs<\/p><\/td><td><p>Evening and night; gone by the morning<\/p><\/td><td><p>Gentle massage and warmth<\/p><\/td><td><p>Only in children aged 3 to 12: it does not explain the pain of an adult woman<\/p><\/td><\/tr>\n<\/tbody>\n<\/table>\n\n<p>No row is a diagnosis, and one cause does not rule out another: a woman with lipedema can also have cramps, varicose veins or restless legs. The table helps you know <b>what to tell your doctor<\/b>, not to settle the question at home.<\/p>\n\n<p><img loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/lipedemaac.com\/wp-content\/uploads\/2026\/10\/consulta-historia-dolor-nocturno-piernas.webp\" alt=\"Female doctor taking notes while listening to a patient sitting opposite her in a bright consultation room\" title=\"Clinical interview about leg pain at night\" width=\"1600\" height=\"900\" loading=\"lazy\" decoding=\"async\"><\/p>\n\n<h3><b>Why do my legs hurt from the knees down at night?<\/b><\/h3>\n\n<p>Because almost all of the night-time causes concentrate there. A <b>cramp<\/b> usually strikes the calf; the sensations of <b>restless legs<\/b> are felt mainly in the lower legs; <b>neuropathy<\/b> starts in the toes and feet; and the rest pain of <b>artery disease<\/b> sits in the foot and toes. Lipedema, by contrast, can involve the whole leg and <b>stops at the ankle<\/b>.<\/p>\n\n<h2><b>Night leg cramps: the pain that wakes you suddenly<\/b><\/h2>\n\n<p>A cramp is an <b>involuntary, sustained contraction<\/b> of a muscle, very painful, that leaves the muscle hard as a knot. Between <b>50% and 60% of adults<\/b> have had night leg cramps; they are slightly more common in women and become more frequent with age. Most are benign and have no identifiable cause.<\/p>\n\n<p>During a cramp, what works is <b>stretching the muscle firmly<\/b>, or standing up and putting your weight on that leg. To prevent them, the foundation is a <b>daily calf stretch<\/b>, with a last round just before you go to bed. The muscle can stay sore for up to a day afterward.<\/p>\n\n<h3><b>Why do I get leg cramps at night?<\/b><\/h3>\n\n<p>The exact mechanism is not known, but today cramps are attributed more to <b>muscle fatigue and nerve dysfunction<\/b> than to a lack of salts. They are associated with age, intense exercise, pregnancy, some medications, vascular disease, lumbar spinal stenosis and hemodialysis. Dehydration is often mentioned, although studies have not linked it to night leg cramps. If they wake you often, last more than 10 minutes or come with numbness or swelling, talk to your doctor, and <b>do not take quinine on your own<\/b>: because of its adverse effects, medical reviews no longer recommend it as a routine treatment.<\/p>\n\n<h3><b>What vitamin deficiency causes leg pain?<\/b><\/h3>\n\n<p>There is no single vitamin behind leg pain, and taking supplements blindly is not a good idea. What a blood test does look at is <b>iron<\/b>, because iron deficiency is associated with restless legs; <b>vitamin B12<\/b> (and B1 or B6), because a deficiency can damage the nerves and cause burning or tingling; and kidney or thyroid function. And magnesium for cramps? A review of trials concluded that it <b>does not appear to be effective in the general population<\/b>, with a possible small effect in pregnant women.<\/p>\n\n<h2><b>Restless legs: less a pain than an urge to move<\/b><\/h2>\n\n<p><b>Restless legs syndrome<\/b>, also called <b>Willis-Ekbom disease<\/b>, is a common, chronic movement disorder. Its core feature is an <b>irresistible urge to move your legs<\/b>, almost always with unpleasant sensations described as tingling, pulling, burning, itching or &ldquo;something crawling&rdquo;. These sensations <b>start or get worse at rest<\/b>, sitting or lying down, <b>improve when you move<\/b> and follow a clear pattern: <b>they get worse in the evening and at night<\/b>.<\/p>\n\n<p>The International Restless Legs Syndrome Study Group (IRLSSG) added a fifth essential criterion in 2014: the symptoms must <b>not be better explained by another condition<\/b>, such as cramps, venous insufficiency or neuropathy. In other words, the diagnosis requires ruling out precisely the conditions on this page. There is no specific test: it is based on the clinical history, the examination and a <b>blood test to look for iron deficiency<\/b> or other problems.<\/p>\n\n<p>It is more common in <b>women<\/b>, in middle-aged people, in <b>pregnancy<\/b> and in people with iron deficiency anemia, chronic kidney disease, diabetes or neuropathy. Caffeine, alcohol and nicotine can make it worse, and so can some medications.<\/p>\n\n<p>How is it different from a cramp? A cramp <b>hurts<\/b> and the muscle hardens; restless legs are above all an uncomfortable sensation that makes you move, <b>with no visible contraction<\/b>.<\/p>\n\n<h2><b>Venous insufficiency: the heaviness that builds up while you stand<\/b><\/h2>\n\n<p>When the valves in the leg veins do not close properly, blood pools and <b>heaviness, a dull ache and sometimes cramps<\/b> appear. It <b>gets worse after many hours on your feet<\/b> and <b>improves when you raise your legs<\/b>, and it usually comes with varicose veins, swelling and, over time, skin changes and wounds that are slow to close.<\/p>\n\n<p>Venous insufficiency is associated with night leg cramps, although treating it has not been shown to relieve them. It is investigated with a <b>Doppler ultrasound<\/b>. If what you mostly notice is swelling at the end of the day, we go through it step by step in our piece on the <a href=\"\/en\/hard-swollen-leg\/\"><b>hard swollen leg<\/b><\/a>.<\/p>\n\n<h3><b>Why do my legs ache deep inside at night?<\/b><\/h3>\n\n<p>A deep, dull ache &ldquo;on the inside&rdquo; can be the heaviness of <b>venous insufficiency<\/b>, an overworked muscle or, if you have vascular risk factors, the <b>rest pain of artery disease<\/b>. Posture tells them apart: venous pain improves when you raise your legs, and arterial pain <b>when you lower them<\/b>. If it is a single leg, swollen and warm, think of a thrombosis and get seen the same day.<\/p>\n\n<h2><b>Peripheral artery disease: rest pain you should not ignore<\/b><\/h2>\n\n<p><b>Peripheral artery disease<\/b> is the narrowing of the arteries in the legs, almost always due to atherosclerosis. At first it causes pain, burning or tiredness in the calf, thigh or foot <b>when you walk<\/b>, which goes away after a few minutes of rest. It is more common with diabetes, smoking, high cholesterol or high blood pressure, and heart or kidney disease. It mainly affects men over 50, although women can have it too.<\/p>\n\n<p>As the lack of blood flow advances, the pain arrives <b>at rest and at night as well<\/b>: pain or burning in the foot and toes that sometimes makes even the weight of the bedsheet unbearable, and that <b>gets worse when you raise the leg and better when you let it hang<\/b> over the side of the bed. The skin may turn pale or bluish, the foot may feel cold, and <b>wounds on the foot that do not heal<\/b> may appear. At that stage, known as chronic limb-threatening ischemia, the risk of losing the leg is high if it is not treated in time, and you need to be seen <b>the same day<\/b>. It is a different situation when a foot turns cold, pale and painful <b>within a matter of hours<\/b>, with or without loss of strength or feeling: that may be an <b>arterial embolism<\/b>, and you call your <b>local emergency number<\/b>.<\/p>\n\n<h3><b>What does leg pain at rest at night mean?<\/b><\/h3>\n\n<p>It depends on what the pain is like. If it is an urge to move that settles when you walk, it points to <b>restless legs<\/b>; if it is heaviness that improves when you raise your legs, to <b>venous insufficiency<\/b>. But if the pain is in your foot, does not go away at rest and <b>eases when you lower the leg<\/b>, especially with a cold or pale foot, it is a warning sign of <b>artery disease<\/b> and you need to be seen the same day. If the foot has turned cold and pale <b>suddenly<\/b>, within hours, it is an emergency: <b>call your local emergency number<\/b>. That is why raising your legs is not good advice for everyone.<\/p>\n\n<h2><b>Neuropathy: burning and tingling you notice more in bed<\/b><\/h2>\n\n<p><b>Peripheral neuropathy<\/b> is damage to the nerves that supply the limbs. It causes <b>numbness, tingling, burning, pins and needles or deep pain<\/b>, and the pain is described as <b>worse at night<\/b>. It usually starts in the toes and feet. The most common cause is <b>diabetes<\/b>, but it can also be caused by a lack of vitamins B1, B6 or B12, alcohol, kidney disease, an underactive thyroid or some medications.<\/p>\n\n<h3><b>Why do my legs burn at night?<\/b><\/h3>\n\n<p>Burning at night is typical of <b>nerve pain<\/b>: a neuropathy, or the sensations of restless legs, which some people describe as burning. Advanced artery disease can also cause burning in the foot at rest. If the burning comes with loss of feeling in your feet, mention it to your doctor, because you may not notice a small wound. We look at tingling and its causes in more depth in our piece on <a href=\"\/en\/lipedema-tingling-legs\/\"><b>tingling in the legs<\/b><\/a>.<\/p>\n\n<h2><b>Deep vein thrombosis: when it is only one leg<\/b><\/h2>\n\n<p>A <b>deep vein thrombosis<\/b> is a clot in a deep vein of the leg or thigh. It is not a &ldquo;night&rdquo; pain: it can appear at any time, and it almost always affects <b>one side<\/b>, with pain or tenderness, swelling, and warm, reddened skin. It is more likely after recent surgery, a long journey sitting down, pregnancy or recent childbirth, with contraceptives or estrogen, and with a family history of clots. It is investigated with a <b>D-dimer<\/b> blood test and a <b>Doppler ultrasound<\/b>.<\/p>\n\n<h3><b>Why does only one leg hurt at night?<\/b><\/h3>\n\n<p>Pain in a single leg means thinking first of what is <b>not symmetrical<\/b>: a thrombosis, especially if the leg is swollen and warm, artery disease that affects one side more, or a local problem such as an overworked muscle or a cramp that keeps coming back in the same calf. Restless legs, diabetic neuropathy and lipedema are usually felt <b>in both legs<\/b>, even if one bothers you more. If a leg swells and hurts in a way that is new for you, do not wait to see whether it passes.<\/p>\n\n<h3><b>What about leg pain at night in children?<\/b><\/h3>\n\n<p>In children aged 3 to 12 there are the so-called <b>growing pains<\/b>: pain or throbbing in both legs, in the evening or at night, which has gone by the morning. They are harmless and, despite the name, they are not caused by growth. A child should see a doctor if the pain is in only one leg, appears in the morning, causes a limp, or comes with fever, swelling or bruising. In an adult woman, growing pains are not the explanation for night-time leg pain.<\/p>\n\n<h2><b>Lipedema: pain that goes with the tissue and with the day<\/b><\/h2>\n\n<p>Lipedema (spelled <i>lipoedema<\/i> in British English) is a <b>disproportionate, symmetrical increase in fat in the limbs<\/b>, almost exclusive to women, and the reference clinical guideline (S2k, 2024) defines it as <b>painful by definition<\/b> (Recommendation 1.1, 100% consensus): if the disproportionate fat does not hurt, it is not called lipedema. Pain is the <b>key symptom<\/b>. The guideline recognizes <b>pain on pressure and touch, spontaneous pain and a feeling of heaviness<\/b> as symptoms (Recommendation 2.1, 100% consensus).<\/p>\n\n<p>And at night? Here it is worth being honest: <b>the guideline does not describe a night-time pattern specific to lipedema<\/b>. What it does record is a very common account: many patients describe a <b>feeling of swelling that increases over the course of the day<\/b>. A comparative study could not measure that increase, so the guideline interprets it as <b>part of the pain experience<\/b>. So if you go to bed with that feeling of swelling and pain after a long day, it fits what many patients with lipedema describe; if what wakes you is a cramp or an urge to move, another cause is most likely involved as well.<\/p>\n\n<p>Another nuance that contradicts much of what you will read elsewhere: the guideline makes clear that lipedema is <b>not primarily an edema disease, nor a problem of the veins or the lymphatic system<\/b>, although it can coexist with venous insufficiency or lymphedema and add their swelling. That is why the differential diagnosis with <b>obesity, lymphedema, venous insufficiency and cellulite<\/b> is part of the assessment; we explain how to tell <a href=\"\/en\/lipedema-or-lymphedema\/\"><b>lipedema and lymphedema<\/b><\/a> apart in a separate piece. You will find the other signs in the <a href=\"\/en\/lipedema-symptoms\/\"><b>symptoms of lipedema<\/b><\/a>.<\/p>\n\n<h2><b>How to relieve leg pain at night, depending on the cause<\/b><\/h2>\n\n<h3><b>How can I relieve leg pain at night?<\/b><\/h3>\n\n<ul>\n<li><p><b>If it is cramps:<\/b> calf stretches several times a day, with the last round before you go to sleep. Drinking enough is a good habit, but dehydration has not been shown to cause night leg cramps. During a cramp, stretch or stand up.<\/p><\/li>\n<li><p><b>If it is restless legs:<\/b> regular sleep times, avoiding caffeine, alcohol and tobacco, gentle stretching, massage or a warm bath, and asking your doctor for an iron test.<\/p><\/li>\n<li><p><b>If it is venous heaviness:<\/b> raise your legs, avoid spending many hours standing or sitting still, and walk every day. Compression stockings are something to discuss with your doctor.<\/p><\/li>\n<li><p><b>If you suspect an arterial problem:<\/b> do not raise your legs to relieve it, and do not wait. That pain needs to be seen by a doctor.<\/p><\/li>\n<li><p><b>If it is lipedema:<\/b> the S2k guideline recommends <b>compression to reduce pain<\/b> (Recommendation 4.1, 100% consensus), while making clear that it does not reduce the fat (Recommendation 4.4), and calls for <b>movement in compression or an exercise program<\/b> to be included as part of pain treatment (Recommendation 7.2, 100% consensus). We explain both in <a href=\"\/en\/compression-garments-lipedema\/\"><b>compression garments for lipedema<\/b><\/a> and in <a href=\"\/en\/lipedema-exercises\/\"><b>exercises for lipedema<\/b><\/a>.<\/p><\/li>\n<\/ul>\n\n<p><img loading=\"lazy\" class=\"aligncenter\" src=\"https:\/\/lipedemaac.com\/wp-content\/uploads\/2026\/10\/estiramiento-gemelo-pared-noche.webp\" alt=\"Woman in a warmly lit bedroom stretching her calf with her hands against the wall and her heel on the floor\" title=\"Calf stretch before bed to help prevent night leg cramps\" width=\"1600\" height=\"900\" loading=\"lazy\" decoding=\"async\"><\/p>\n\n<h2><b>Where we can assess it for you, and where we cannot<\/b><\/h2>\n\n<p>If your night-time pain matches any of the warning signs at the top of this page, the path is not a lipedema clinic: it is <b>the emergency department or your family doctor<\/b>. Cramps and restless legs are also better investigated by your family doctor.<\/p>\n\n<p>If what you notice is pain on pressure in fatty tissue that is <b>symmetrical and disproportionate<\/b> in both legs, with a feeling of swelling that increases over the day, and you have spent a long time hearing that it is &ldquo;poor circulation&rdquo; or &ldquo;just tiredness&rdquo;, that is something we do assess. At our clinic in Valencia, Spain, the assessment includes the differential diagnosis with obesity, lymphedema, venous insufficiency and cellulite, and <b>the team sees international patients in English<\/b>. We explain what is examined on our page on <a href=\"\/en\/lipedema-diagnosis\/\"><b>lipedema diagnosis<\/b><\/a>, and if you are considering traveling, the practical details are set out for <a href=\"\/en\/international-patients\/\"><b>international patients<\/b><\/a>. If it is not lipedema, we will tell you: ruling things out is part of the job too.<\/p>\n\n<hr \/>\n\n<h3><b>Sources and references<\/b><\/h3>\n\n<ul>\n<li><p><a href=\"https:\/\/register.awmf.org\/assets\/guidelines\/037-012l_S2k_Lipoedem_2024-01_01.pdf\" target=\"_blank\" rel=\"noopener\"><b>Guideline S2k Lipoedema, AWMF 037-012, version 5.0 (2024)<\/b><\/a>. Recommendations 1.1, 2.1, 2.10, 4.1, 4.4 and 7.2; pain as the key symptom, perceived swelling over the course of the day, and lipedema as a disease that is not primarily edematous, venous or lymphatic.<\/p><\/li>\n<li><p><a href=\"https:\/\/www.aafp.org\/pubs\/afp\/issues\/2012\/0815\/p350.html\" target=\"_blank\" rel=\"noopener\"><b>Allen RE, Kirby KA. Nocturnal Leg Cramps. Am Fam Physician, 2012<\/b><\/a>. Frequency, mechanism, associations and differential diagnosis with restless legs.<\/p><\/li>\n<li><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/29763070\/\" target=\"_blank\" rel=\"noopener\"><b>Muscle Cramps. StatPearls<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/www.nhs.uk\/conditions\/leg-cramps\/\" target=\"_blank\" rel=\"noopener\"><b>Leg cramps. NHS<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/24280947\/\" target=\"_blank\" rel=\"noopener\"><b>Sebo P et al. Effect of magnesium therapy on nocturnal leg cramps. Fam Pract, 2014<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28613628\/\" target=\"_blank\" rel=\"noopener\"><b>Restless Legs Syndrome. StatPearls<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/25023924\/\" target=\"_blank\" rel=\"noopener\"><b>Allen RP et al. Restless legs syndrome\/Willis-Ekbom disease diagnostic criteria: updated IRLSSG consensus criteria. Sleep Med, 2014<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000807.htm\" target=\"_blank\" rel=\"noopener\"><b>Restless legs syndrome. MedlinePlus<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000203.htm\" target=\"_blank\" rel=\"noopener\"><b>Venous insufficiency. MedlinePlus<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000170.htm\" target=\"_blank\" rel=\"noopener\"><b>Peripheral artery disease, legs. MedlinePlus<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28613496\/\" target=\"_blank\" rel=\"noopener\"><b>Peripheral Arterial Disease. StatPearls<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/28723038\/\" target=\"_blank\" rel=\"noopener\"><b>Diabetic Peripheral Neuropathy. StatPearls<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000593.htm\" target=\"_blank\" rel=\"noopener\"><b>Peripheral neuropathy. MedlinePlus<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/000156.htm\" target=\"_blank\" rel=\"noopener\"><b>Deep vein thrombosis. MedlinePlus<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/001102.htm\" target=\"_blank\" rel=\"noopener\"><b>Arterial embolism. MedlinePlus<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/www.nhs.uk\/conditions\/peripheral-arterial-disease-pad\/\" target=\"_blank\" rel=\"noopener\"><b>Peripheral arterial disease (PAD). NHS<\/b><\/a>. Critical limb ischemia: contact a doctor immediately.<\/p><\/li>\n<li><p><a href=\"https:\/\/medlineplus.gov\/ency\/article\/003206.htm\" target=\"_blank\" rel=\"noopener\"><b>Numbness and tingling. MedlinePlus<\/b><\/a>.<\/p><\/li>\n<li><p><a href=\"https:\/\/www.nhs.uk\/conditions\/growing-pains\/\" target=\"_blank\" rel=\"noopener\"><b>Growing pains. NHS<\/b><\/a>.<\/p><\/li>\n<\/ul>\n\n<hr \/>\n\n<p><b>Content prepared by the medical team at Lipedema Advanced Care<\/b> based on the S2k lipedema guideline (AWMF 037-012, 2024 version) and the sources cited.<br \/>Published in October 2026.<\/p>\n\n<p><i>This page is for information purposes and does not replace a medical consultation. The diagnosis of lipedema is clinical and must be made by an experienced professional. Call your local emergency number now (112 in Spain and the EU, 999 in the UK, 911 in the US) or go to the emergency department if a foot or leg suddenly turns cold, pale and painful; if sudden weakness or loss of strength or feeling appears, you cannot control your leg, you have difficulty walking or you lose bladder or bowel control; or if leg pain comes with chest pain, shortness of breath or coughing up blood, or weakness with difficulty speaking, changes in vision or confusion. Get medical attention the same day if you have pain at rest that has lasted for weeks and eases when you let the leg hang down, a wound on your foot that will not heal, or a single leg that is swollen, warm and painful.<\/i><\/p>\n\n<script type=\"application\/ld+json\">\n{\n    \"@context\": \"https:\/\/schema.org\",\n    \"@type\": \"FAQPage\",\n    \"mainEntity\": [\n        {\n            \"@type\": \"Question\",\n            \"name\": \"When should I worry about leg pain at night?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"Call your local emergency number (112 in Spain and the EU, 999 in the UK, 911 in the US) or go to the emergency department if a foot or leg suddenly turns cold, pale and painful, if sudden weakness or loss of feeling appears, you cannot control your leg, walking becomes difficult or you lose bladder or bowel control, or if there is chest pain or shortness of breath. Get seen the same day for rest pain lasting weeks that eases when the leg hangs down, a foot wound that will not heal or a single swollen, warm leg.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"Why do my legs hurt from the knees down at night?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"Because almost all of the night-time causes concentrate in that area. A cramp usually affects the calf, the sensations of restless legs are felt mainly in the lower legs, neuropathy starts in the toes and feet, and the rest pain of peripheral artery disease sits in the foot and toes. Lipedema, by contrast, can involve the whole leg, is symmetrical and stops at the ankle, sparing the feet.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"Why do I get leg cramps at night?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"The exact mechanism is not known, but today night leg cramps are attributed more to muscle fatigue and nerve dysfunction than to a lack of salts. They are associated with age, intense exercise, pregnancy, some medications, vascular disease, lumbar spinal stenosis and hemodialysis. Dehydration is often mentioned, although studies have not linked it to night leg cramps. If they wake you often or last more than 10 minutes, it is worth talking to your doctor.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"What vitamin deficiency causes leg pain?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"There is no single vitamin behind leg pain, and taking supplements blindly is not a good idea. A blood test looks for iron deficiency, which is associated with restless legs; vitamin B12, B1 or B6 deficiency, which can damage the nerves and cause burning or tingling; and kidney or thyroid function. As for magnesium for cramps, a review of trials concluded that it does not appear to be effective in the general population, with a possible small effect in pregnant women.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"Why do my legs ache deep inside at night?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"A deep, dull ache can be the heaviness of venous insufficiency, an overworked muscle or, in someone with vascular risk factors, the rest pain of peripheral artery disease. Posture is what separates them most: venous pain improves when you raise your legs, and arterial pain improves when you lower them. If the deep pain is in a single leg and that leg is swollen and warm, think of a thrombosis and get seen the same day.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"What does leg pain at rest at night mean?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"It depends on what the pain is like. An urge to move that settles when you walk points to restless legs, and heaviness that improves when you raise your legs points to venous insufficiency. Foot pain that has been appearing at rest for weeks and eases when the leg hangs down, with a cold or pale foot, points to artery disease and needs to be seen the same day. If the foot turns cold, pale and painful suddenly, within hours, it may be an arterial embolism: call your local emergency number.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"Why do my legs burn at night?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"Burning at night is typical of nerve pain: a peripheral neuropathy, whose most common cause is diabetes, or the sensations of restless legs, which some people describe as burning. Advanced artery disease can also cause burning in the foot at rest. If the burning comes with loss of feeling in your feet, mention it to your doctor, because a small wound could go unnoticed.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"Why does only one leg hurt at night?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"Pain in a single leg means thinking first of causes that are not symmetrical: a deep vein thrombosis, especially if the leg is swollen and warm, artery disease that affects one side more, or a local problem such as an overworked muscle or a cramp that keeps coming back in the same calf. Restless legs, diabetic neuropathy and lipedema are usually felt in both legs, even if one bothers you more. If a leg swells and hurts in a new way, do not wait.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"What about leg pain at night in children?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"In children aged 3 to 12 there are the so-called growing pains: pain or throbbing in both legs, in the evening or at night, which has gone by the morning. They are harmless and, despite the name, they are not caused by growth. A child should see a doctor if the pain is in only one leg, appears in the morning, causes a limp or comes with fever, swelling or bruising. In an adult woman, growing pains do not explain night-time leg pain.\"\n            }\n        },\n        {\n            \"@type\": \"Question\",\n            \"name\": \"How can I relieve leg pain at night?\",\n            \"acceptedAnswer\": {\n                \"@type\": \"Answer\",\n                \"text\": \"It depends on the cause. For cramps, a daily calf stretch with a round before bed. For restless legs, regular sleep times, avoiding caffeine, alcohol and tobacco, and asking for an iron test. For venous heaviness, raising your legs and walking every day. If you suspect an arterial problem, do not raise your legs and get seen without waiting. In lipedema, the S2k guideline recommends compression and movement to reduce pain.\"\n            }\n        }\n    ]\n}\n<\/script>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b9eb2c7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b9eb2c7\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-498d504\" data-id=\"498d504\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68693c4 elementor-widget elementor-widget-spacer\" data-id=\"68693c4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"spacer.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-spacer\">\n\t\t\t<div class=\"elementor-spacer-inner\"><\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d98e29 elementor-widget elementor-widget-author-box\" data-id=\"3d98e29\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"author-box.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-author-box\">\n\t\t\t\t\t\t\t<a href=\"https:\/\/lipedemaac.com\/en\/doctor-alexo-carballeira-brana\/\" class=\"elementor-author-box__avatar\">\n\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/lipedemaac.com\/wp-content\/uploads\/2026\/08\/dr-alexo-carballeira.png\" alt=\"Dr Alexo Carballeira \u2013 Medical Director\" title=\"\">\n\t\t\t\t<\/a>\n\t\t\t\n\t\t\t<div class=\"elementor-author-box__text\">\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/lipedemaac.com\/en\/doctor-alexo-carballeira-brana\/\">\n\t\t\t\t\t\t<div class=\"elementor-author-box__name\">\n\t\t\t\t\t\t\tDr Alexo Carballeira \u2013 Medical Director\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/a>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-author-box__bio\">\n\t\t\t\t\t\t<p>Dr Alexo Carballeira trained at prestigious national and international universities, perfecting his technique alongside world leaders in plastic surgery such as Dr Ivo Pitanguy and Dr Pedro Cavadas. He holds a degree in Medicine and is a specialist in Plastic, Aesthetic and Reconstructive Surgery. He also has an International Master's Degree in Reconstructive Microsurgery.<\/p>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>If your legs hurt at night, the explanation is almost always benign: the most common causes are night leg cramps, restless legs syndrome and the heaviness of venous insufficiency. But there is one kind of leg pain at night that should not be left until morning: a cold, pale foot that hurts at rest and [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":8182,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[65],"tags":[],"class_list":["post-7719","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-lipedema"],"_links":{"self":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/posts\/7719","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/comments?post=7719"}],"version-history":[{"count":7,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/posts\/7719\/revisions"}],"predecessor-version":[{"id":8188,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/posts\/7719\/revisions\/8188"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/media\/8182"}],"wp:attachment":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/media?parent=7719"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/categories?post=7719"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/tags?post=7719"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}