{"id":3712,"date":"2025-09-03T12:23:56","date_gmt":"2025-09-03T12:23:56","guid":{"rendered":"https:\/\/lipedemaac.com\/causas-del-lipedema\/"},"modified":"2026-08-06T10:20:53","modified_gmt":"2026-08-06T10:20:53","slug":"causes-of-lipedema","status":"publish","type":"page","link":"https:\/\/lipedemaac.com\/en\/causes-of-lipedema\/","title":{"rendered":"Causes of Lipedema"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"3712\" class=\"elementor elementor-3712\" data-elementor-settings=\"{&quot;ha_cmc_init_switcher&quot;:&quot;no&quot;}\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-23b8d62 elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"23b8d62\" data-element_type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;_ha_eqh_enable&quot;:false}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-no\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-7e8b8c0\" data-id=\"7e8b8c0\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f56d271 elementor-widget elementor-widget-html\" data-id=\"f56d271\" data-element_type=\"widget\" data-widget_type=\"html.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<!--\r\n=====================================================================\r\n\/en\/causes-of-lipedema\/  -  FULL PAGE (ALL IN ONE)  -  EN\r\nInformational landing used transactionally: premium hero + blog-style body.\r\nPaste into a block that PROCESSES shortcodes (Gutenberg \"Custom HTML\" or Elementor).\r\nIncludes the rich snippet (JSON-LD) at the end and the WPForms shortcode (form 3655).\r\nINFOGRAPHIC: the \"Possible causes of lipedema\" graphic is rebuilt in HTML+SVG (.lacinf block),\r\nnot as an image. 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!important;margin-left:auto !important;margin-right:auto !important;display:grid;gap:14px;}\r\n.cslac-faq-item{background:#fff;border:1px solid rgba(180,151,95,.22);padding:24px 28px;box-shadow:0 18px 50px rgba(0,0,0,.045);}\r\n.cslac-faq-item h3{margin:0 0 10px;font-size:18px;}\r\n.cslac-faq-item p{margin:0;color:#555;font-size:16px;line-height:1.8;}\r\n.cslac-faq-item p a{color:#9b7b3d;font-weight:700;text-decoration:none;}\r\n\r\n\/* AUTOR \/ FUENTES *\/\r\n.cslac-section .cslac-authorbox{max-width:1180px;margin-left:auto !important;margin-right:auto !important;background:#fff;border:1px solid rgba(180,151,95,.28);border-left:4px solid #b4975f;padding:30px 34px;}\r\n.cslac-authorbox p{margin:0 0 10px;color:#3b3b3b;font-size:14.5px;line-height:1.7;}\r\n.cslac-authorbox p:last-child{margin:0;}\r\n.cslac-authorbox strong{color:#111;}\r\n.cslac-authorbox a{color:#9b7b3d;font-weight:700;text-decoration:none;}\r\n.cslac-section .cslac-refs{max-width:920px;margin-left:auto !important;margin-right:auto !important;}\r\n.cslac-refs h3{color:#111;font-size:15px;text-transform:uppercase;letter-spacing:.1em;}\r\n.cslac-refs ol{color:#666;font-size:13.5px;line-height:1.7;padding-left:18px;}\r\n.cslac-refs a{color:#9b7b3d;text-decoration:none;}\r\n\r\n@media(max-width:820px){.cslac-section{padding:56px 20px;}}\r\n@media(max-width:767px){\r\n  .cslac-hero{min-height:560px;background-position:72% center;}\r\n  .cslac-hero::before{background:linear-gradient(180deg, rgba(5,8,9,.96) 0%, rgba(5,8,9,.84) 45%, rgba(5,8,9,.96) 100%);}\r\n  .cslac-hero-inner{padding:92px 22px 56px;}\r\n  .cslac-actions{flex-direction:column;}\r\n  .cslac-btn-primary,.cslac-btn-secondary{width:100%;}\r\n}\r\n<\/style>\r\n\r\n<!-- ============================= HERO ============================= -->\r\n<section class=\"cslac-hero\">\r\n  <div class=\"cslac-hero-inner\">\r\n    <div class=\"cslac-hero-content\">\r\n      <div class=\"cslac-kicker\">Causes of lipedema<\/div>\r\n      <h1>Causes of lipedema:<span>why it appears<\/span><\/h1>\r\n      <p class=\"cslac-hero-text\">\r\n        The exact cause of lipedema is still unknown, but we do know a good deal about what influences it: there is a clear <strong>genetic component<\/strong> and a close <strong>relationship with hormones<\/strong>, which explains why it almost always appears in women and at specific moments in life. And there is something just as important: <strong>it is not caused by diet or a lack of exercise<\/strong>.\r\n      <\/p>\r\n      <div class=\"cslac-hero-links\">\r\n        <a href=\"\/en\/what-is-lipedema\/\">What is lipedema<\/a>\r\n        <a href=\"\/en\/lipedema-symptoms\/\">Symptoms<\/a>\r\n        <a href=\"\/en\/stages-of-lipedema\/\">Stages and types<\/a>\r\n        <a href=\"\/en\/lipedema-diagnosis\/\">Diagnosis<\/a>\r\n        <a href=\"\/en\/lipedema-test\/\">Lipedema test<\/a>\r\n      <\/div>\r\n      <div class=\"cslac-actions\">\r\n        <a href=\"#contacto_footer\" class=\"cslac-btn-primary\">Request a concierge assessment<\/a>\r\n        <a href=\"\/en\/lipedema-diagnosis\/\" class=\"cslac-btn-secondary\">See the diagnosis<\/a>\r\n      <\/div>\r\n    <\/div>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= INTRO ============================= -->\r\n<section class=\"cslac-section white\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-prose\">\r\n      <div class=\"cslac-eyebrow\">The starting point<\/div>\r\n      <h2>First, honestly: <span>the exact cause is not known<\/span><\/h2>\r\n      <p>\r\n        If you have come here looking for a clear explanation of why this has happened to you, we owe you an honest answer: <strong>the ultimate cause of lipedema has still not been established<\/strong>. That is not a failing of your doctor or a gap in your particular case: it is the current state of knowledge about this condition.\r\n      <\/p>\r\n      <p>\r\n        That said, \"not knowing the exact cause\" does not mean knowing nothing. We know there is a <strong>genetic predisposition<\/strong>, we know that <strong>hormones<\/strong> play a decisive role in when it appears and when it worsens, and we know with reasonable confidence <strong>what does NOT cause it<\/strong>. For many patients, that last part is the most reassuring.\r\n      <\/p>\r\n    <\/div>\r\n\r\n    <style>\r\n.lacinf{--lacinf-bg:#EAF3FB;--lacinf-circle:#B6D6F2;--lacinf-ink:#1B4F8C;\r\n  background:var(--lacinf-bg);padding:clamp(28px,4vw,52px) clamp(18px,3vw,44px);\r\n  font-family:'Manrope',sans-serif;border:1px solid rgba(27,79,140,.10);}\r\n.lacinf h3{margin:0 0 clamp(24px,3vw,38px);text-align:center;color:var(--lacinf-ink) !important;\r\n  font-family:inherit !important;font-size:clamp(22px,3vw,36px) !important;font-weight:800 !important;line-height:1.2 !important;letter-spacing:-.01em;}\r\n.lacinf h3 span{font-weight:400;}\r\n.lacinf-grid{display:grid;grid-template-columns:1fr auto 1fr;gap:clamp(10px,2vw,26px);align-items:start;max-width:820px;margin:0 auto;}\r\n.lacinf-item{text-align:center;}\r\n.lacinf-circle{width:clamp(90px,13vw,150px);height:clamp(90px,13vw,150px);border-radius:50%;background:var(--lacinf-circle);\r\n  display:flex;align-items:center;justify-content:center;margin:0 auto clamp(12px,1.6vw,20px);}\r\n.lacinf-circle svg{width:52%;height:52%;display:block;}\r\n.lacinf-item p{margin:0 !important;color:var(--lacinf-ink) !important;font-size:clamp(14px,1.5vw,19px) !important;\r\n  font-weight:700 !important;line-height:1.35 !important;}\r\n.lacinf-plus{align-self:center;color:var(--lacinf-ink);font-size:clamp(26px,3.4vw,46px);font-weight:800;line-height:1;\r\n  padding-top:clamp(28px,4vw,52px);}\r\n.lacinf-row2{margin-top:clamp(24px,3vw,40px);}\r\n@media(max-width:600px){\r\n  .lacinf-grid{grid-template-columns:1fr 1fr;gap:16px;}\r\n  .lacinf-plus{display:none;}\r\n  .lacinf-row2{margin-top:22px;}\r\n}\r\n<\/style>\r\n<div class=\"lacinf\" role=\"img\" aria-label=\"Possible causes of lipedema: genetic factor, hormonal factors, microvascular and lymphatic changes and altered fat tissue metabolism\">\r\n  <h3>Possible causes <span>of lipedema<\/span><\/h3>\r\n  <div class=\"lacinf-grid\">\r\n    <div class=\"lacinf-item\"><div class=\"lacinf-circle\"><svg viewBox=\"0 0 64 64\" fill=\"none\" stroke=\"#1B4F8C\" stroke-width=\"2.6\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M20 8c0 10 24 14 24 24S20 46 20 56\"\/><path d=\"M44 8c0 10-24 14-24 24s24 14 24 24\"\/><path d=\"M23 16h18M20.5 24h23M20.5 40h23M23 48h18\"\/><\/svg><\/div><p>Genetic factor<\/p><\/div>\r\n    <div class=\"lacinf-plus\">+<\/div>\r\n    <div class=\"lacinf-item\"><div class=\"lacinf-circle\"><svg viewBox=\"0 0 64 64\" fill=\"none\" stroke=\"#1B4F8C\" stroke-width=\"2.8\" stroke-linecap=\"round\" aria-hidden=\"true\"><circle cx=\"32\" cy=\"24\" r=\"13\"\/><path d=\"M32 37v19M24 48h16\"\/><\/svg><\/div><p>Hormonal factors<\/p><\/div>\r\n  <\/div>\r\n  <div class=\"lacinf-grid lacinf-row2\">\r\n    <div class=\"lacinf-item\"><div class=\"lacinf-circle\"><svg viewBox=\"0 0 64 64\" fill=\"none\" stroke=\"#1B4F8C\" stroke-width=\"2.6\" stroke-linecap=\"round\" aria-hidden=\"true\"><path d=\"M32 56V30M32 34l-11-9M32 34l11-9M32 24l-7-7M32 24l7-7\"\/><circle cx=\"19\" cy=\"24\" r=\"3.4\" fill=\"#1B4F8C\" stroke=\"none\"\/><circle cx=\"45\" cy=\"24\" r=\"3.4\" fill=\"#1B4F8C\" stroke=\"none\"\/><circle cx=\"23\" cy=\"15\" r=\"3.4\" fill=\"#1B4F8C\" stroke=\"none\"\/><circle cx=\"41\" cy=\"15\" r=\"3.4\" fill=\"#1B4F8C\" stroke=\"none\"\/><circle cx=\"32\" cy=\"9\" r=\"3.4\" fill=\"#1B4F8C\" stroke=\"none\"\/><\/svg><\/div><p>Microvascular and lymphatic changes<\/p><\/div>\r\n    <div class=\"lacinf-plus\">+<\/div>\r\n    <div class=\"lacinf-item\"><div class=\"lacinf-circle\"><svg viewBox=\"0 0 64 64\" fill=\"none\" stroke=\"#1B4F8C\" stroke-width=\"2.6\" aria-hidden=\"true\"><ellipse cx=\"32\" cy=\"32\" rx=\"20\" ry=\"24\"\/><circle cx=\"25\" cy=\"23\" r=\"5\"\/><circle cx=\"40\" cy=\"28\" r=\"6.5\"\/><circle cx=\"27\" cy=\"41\" r=\"6\"\/><circle cx=\"40\" cy=\"44\" r=\"3.6\"\/><circle cx=\"34\" cy=\"15\" r=\"2.6\"\/><\/svg><\/div><p>Altered fat tissue metabolism<\/p><\/div>\r\n  <\/div>\r\n<\/div>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= WHAT DOES NOT CAUSE IT ============================= -->\r\n<section class=\"cslac-section\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-prose\">\r\n      <div class=\"cslac-eyebrow\">Let us start here<\/div>\r\n      <h2>What does <span>NOT<\/span> cause lipedema<\/h2>\r\n      <p>\r\n        Almost every patient who comes to the clinic has spent years hearing some version of \"you eat badly\" or \"you need to move more\". It is worth dismantling that before going any further, because misplaced blame is what delays the diagnosis.\r\n      <\/p>\r\n    <\/div>\r\n\r\n    <div class=\"cslac-myths\">\r\n      <div class=\"cslac-myth\">\r\n        <span class=\"m\">Myth<\/span>\r\n        <p>\"You have lipedema because you eat badly.\"<\/p>\r\n        <span class=\"r\">What we know<\/span>\r\n        <p>Lipedema is not caused by diet. Lipedema fat tissue behaves differently from ordinary fat: it responds far less to a calorie deficit than the rest of the body. That is why many women lose weight from the face, torso and chest, and barely any from the legs or arms.<\/p>\r\n      <\/div>\r\n      <div class=\"cslac-myth\">\r\n        <span class=\"m\">Myth<\/span>\r\n        <p>\"If you exercised more, it would go away.\"<\/p>\r\n        <span class=\"r\">What we know<\/span>\r\n        <p>Exercise is beneficial and part of the management, but it does not remove lipedema tissue. There are highly active, athletic patients with lipedema. The lack of response to exercise is in fact one of the signs that points to the diagnosis. The same applies to weight-loss approaches, including <strong>bariatric surgery<\/strong>: they do achieve weight loss and can reduce volume, but lipedema tissue is <strong>resistant to reduction<\/strong> and the pain and disproportion tend to persist, because proportionally more fat is lost from the trunk.<\/p>\r\n      <\/div>\r\n      <div class=\"cslac-myth\">\r\n        <span class=\"m\">Myth<\/span>\r\n        <p>\"You are just overweight, it is the same thing.\"<\/p>\r\n        <span class=\"r\">What we know<\/span>\r\n        <p>They are different things and can coexist. Obesity distributes fat generally; lipedema does so symmetrically in the legs or arms, sparing the hands and feet, and it hurts. You can have lipedema at a normal weight.<\/p>\r\n      <\/div>\r\n      <div class=\"cslac-myth\">\r\n        <span class=\"m\">Myth<\/span>\r\n        <p>\"It is cellulite, everyone has it.\"<\/p>\r\n        <span class=\"r\">What we know<\/span>\r\n        <p>Cellulite is a superficial cosmetic feature that does not usually hurt. Lipedema is a condition: it hurts on pressure, causes easy bruising and produces disproportion. We compare them in <a class=\"cslac-link\" href=\"\/en\/difference-lipedema-cellulite\/\">lipedema or cellulite<\/a>.<\/p>\r\n      <\/div>\r\n    <\/div>\r\n\r\n    <div class=\"cslac-callout\">\r\n      <p><strong>An important and honest caveat:<\/strong> the fact that diet does not cause lipedema does not mean weight is irrelevant. Gaining weight can worsen the symptoms and make management harder, and looking after nutrition and movement remains part of the approach. The cause is one thing; the factors that influence how it develops are another.<\/p>\r\n    <\/div>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= KNOWN FACTORS ============================= -->\r\n<section class=\"cslac-section white\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-lead\">\r\n      <div class=\"cslac-eyebrow\">What we do know<\/div>\r\n      <h2>The factors that do play a role<\/h2>\r\n      <p style=\"max-width:780px;margin:0 auto 44px;\">Lipedema is considered a multifactorial condition: there is no single culprit, but a combination of predisposition and triggers.<\/p>\r\n    <\/div>\r\n\r\n    <div class=\"cslac-cause\">\r\n      <span class=\"cslac-num\">Factor 1<\/span>\r\n      <h3>Genetics: why it runs in the family<\/h3>\r\n      <p>\r\n        This is the best documented factor. It is very common for a patient, when asked, to recognise the same pattern of legs in her <strong>mother, grandmother, sisters or aunts<\/strong>: the literature describes a family history in a large proportion of cases. That familial clustering points to an inherited predisposition, and a pattern consistent with autosomal dominant inheritance with incomplete penetrance and sex limitation has been proposed, although <strong>no single responsible gene has been identified<\/strong>.\r\n      <\/p>\r\n      <h3>Does that mean my daughter will have it?<\/h3>\r\n      <p>\r\n        Not inevitably. Inheriting the predisposition is not the same as developing the condition, and its intensity varies widely between relatives. What the family history does give you is an advantage: it lets you <strong>stay alert and diagnose earlier<\/strong>, which is exactly what tends to fail in lipedema.\r\n      <\/p>\r\n    <\/div>\r\n\r\n    <div class=\"cslac-cause\">\r\n      <span class=\"cslac-num\">Factor 2<\/span>\r\n      <h3>Hormones: why it appears at those particular moments<\/h3>\r\n      <p>\r\n        If genetics explains <em>who<\/em>, hormones explain <em>when<\/em>. Lipedema almost always appears or worsens alongside stages of hormonal change, something current clinical guidelines set out.\r\n      <\/p>\r\n    <\/div>\r\n\r\n    <div class=\"cslac-tablewrap\">\r\n      <table class=\"cslac-table\">\r\n        <thead><tr><th>Stage or situation<\/th><th>What usually happens<\/th><\/tr><\/thead>\r\n        <tbody>\r\n          <tr><td>Puberty<\/td><td>The most frequent stage of first onset. It usually starts as a disproportion between the upper and lower body.<\/td><\/tr>\r\n          <tr><td>Pregnancy and postpartum<\/td><td>Can trigger the onset or accentuate existing lipedema, with an increase in volume that does not fully reverse.<\/td><\/tr>\r\n          <tr><td>Menopause<\/td><td>Another common moment of worsening, with more heaviness and increased volume.<\/td><\/tr>\r\n          <tr><td>Hormonal contraception<\/td><td>Some patients link the onset or worsening to changes in their hormonal treatment. It is worth mentioning in consultation.<\/td><\/tr>\r\n          <tr><td>Associated conditions<\/td><td>Some patients with lipedema also have polycystic ovary syndrome (PCOS) or endometriosis, both hormone-sensitive conditions. Occurring together does not mean causing, but it is worth assessing as a whole.<\/td><\/tr>\r\n        <\/tbody>\r\n      <\/table>\r\n    <\/div>\r\n    <p class=\"cslac-tnote\">The link with hormonal phases is set out in the German S2k guideline on lipedema (AWMF 037-012, 2024), which notes that the first manifestation or an increase in symptoms almost always occurs during periods of hormonal change.<\/p>\r\n\r\n    <div class=\"cslac-cause\" style=\"margin-top:44px;\">\r\n      <span class=\"cslac-num\">Factor 3<\/span>\r\n      <h3>At what age does lipedema appear?<\/h3>\r\n      <p>\r\n        There is no single age, but there is a pattern that follows the hormonal calendar. The <strong>first manifestation most often occurs at puberty and in adolescence<\/strong>: around half of cases have been reported to begin at that stage. From then on, the moments of change shape how it develops.\r\n      <\/p>\r\n      <p>\r\n        It is common for a woman, looking back, to recognise that \"her legs were always like that\" since adolescence, and that the problem became obvious after a pregnancy or on reaching menopause. That trajectory, rather than a specific age, is the signal we look for in consultation.\r\n      <\/p>\r\n    <\/div>\r\n\r\n    <div class=\"cslac-cause\">\r\n      <span class=\"cslac-num\">Factor 4<\/span>\r\n      <h3>Why it affects almost only women<\/h3>\r\n      <p>\r\n        Precisely because of the above: the weight of the hormonal component makes lipedema <strong>almost exclusive to women<\/strong>. In men it is <strong>extremely rare<\/strong>: the literature contains only isolated case reports. These are assumed to be usually associated with a significant disruption of hormonal balance, although cases without one have also been published.\r\n      <\/p>\r\n      <p>\r\n        This has a practical consequence that is rarely discussed: being an almost exclusively female condition with an apparent cosmetic component, it has historically been <strong>underdiagnosed and played down<\/strong>. Many patients face not just the condition, but years of not being believed.\r\n      <\/p>\r\n    <\/div>\r\n\r\n    <div class=\"cslac-cause\">\r\n      <span class=\"cslac-num\">Factor 5<\/span>\r\n      <h3>Inflammation, microcirculation and the lymphatic system<\/h3>\r\n      <p>\r\n        Beyond predisposition and hormones, changes have been described in the tissue itself: a low-grade <strong>inflammatory<\/strong> component, changes in the <strong>small vessels<\/strong> that would explain the tendency to bruise, and an <strong>overload of the lymphatic system<\/strong> which, in advanced phases, can lead to a lymphoedema component.\r\n      <\/p>\r\n      <p>\r\n        That same mechanism explains <a class=\"cslac-link\" href=\"\/en\/why-my-legs-hurt-causes\/\">why the legs hurt<\/a> and why lipedema can also affect the <a class=\"cslac-link\" href=\"\/en\/causes-thick-arms-lipedema\/\">arms<\/a>. These mechanisms are also the reason why the surgical approach must <strong>preserve the lymphatic system<\/strong>: it is not simply about removing fat. We explain this in <a class=\"cslac-link\" href=\"\/en\/lipedema-reduction-surgery\/\">lipedema surgery<\/a> and in the <a class=\"cslac-link\" href=\"\/en\/advanced-care-method\/\">Advanced Care Method<\/a>.\r\n      <\/p>\r\n    <\/div>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= TRIGGERS ============================= -->\r\n<section class=\"cslac-section\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-prose\">\r\n      <div class=\"cslac-eyebrow\">Another frequent question<\/div>\r\n      <h2>Is there anything that can <span>trigger or aggravate<\/span> lipedema?<\/h2>\r\n      <p>\r\n        It is worth separating two ideas that often get mixed up. One is the <strong>cause<\/strong> (the predisposition that was already there); the other is the <strong>factors that can precipitate it becoming apparent or make it worse<\/strong>. Many patients identify a specific moment after which \"everything changed\".\r\n      <\/p>\r\n    <\/div>\r\n    <div class=\"cslac-tablewrap\">\r\n      <table class=\"cslac-table\">\r\n        <thead><tr><th>Factor<\/th><th>What is observed<\/th><\/tr><\/thead>\r\n        <tbody>\r\n          <tr><td>Hormonal changes<\/td><td>The most common trigger: puberty, pregnancy, menopause or changes in hormonal treatment.<\/td><\/tr>\r\n          <tr><td>Weight gain<\/td><td>It does not cause the condition, but it is associated with worsening symptoms and volume.<\/td><\/tr>\r\n          <tr><td>Surgery or trauma<\/td><td>The 2021 US consensus puts it forward as a possible trigger, through tissue remodelling after the procedure or the blow. Some patients date the onset or worsening to that point.<\/td><\/tr>\r\n          <tr><td>Sustained stress<\/td><td>There are no studies establishing it as a cause of lipedema. What has been described is its influence on the perception of pain, which can make symptoms feel more intense.<\/td><\/tr>\r\n        <\/tbody>\r\n      <\/table>\r\n    <\/div>\r\n    <p class=\"cslac-tnote\">These factors do not explain the appearance of lipedema on their own: they act on a pre-existing predisposition. If you can identify a specific moment when you noticed the change, mention it in consultation: it helps to reconstruct the clinical history.<\/p>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= SUMMARY TABLE ============================= -->\r\n<section class=\"cslac-section white\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-prose\">\r\n      <div class=\"cslac-eyebrow\">Summary<\/div>\r\n      <h2>What plays a role and what does not, at a glance<\/h2>\r\n    <\/div>\r\n    <div class=\"cslac-tablewrap\">\r\n      <table class=\"cslac-table\">\r\n        <thead><tr><th>Factor<\/th><th>Does it play a role?<\/th><th>What we know<\/th><\/tr><\/thead>\r\n        <tbody>\r\n          <tr><td>Genetic predisposition<\/td><td>Yes, the best documented factor<\/td><td>Frequent familial clustering; no single gene identified<\/td><\/tr>\r\n          <tr><td>Hormonal changes<\/td><td>Yes, they determine when it appears or worsens<\/td><td>Puberty, pregnancy and menopause as key moments<\/td><\/tr>\r\n          <tr><td>Female sex<\/td><td>Yes, it is almost exclusive to women<\/td><td>Very rare in men<\/td><\/tr>\r\n          <tr><td>Inflammation and lymphatic system<\/td><td>Yes, in how the tissue behaves<\/td><td>They explain the pain, the bruising and the risk of a lymphatic component<\/td><\/tr>\r\n          <tr><td>Diet<\/td><td>Not as a cause<\/td><td>It does not cause the condition, although weight gain can worsen it<\/td><\/tr>\r\n          <tr><td>Sedentary lifestyle<\/td><td>Not as a cause<\/td><td>Exercise helps management but does not remove lipedema tissue<\/td><\/tr>\r\n          <tr><td>Lack of willpower or neglect<\/td><td>No<\/td><td>It is a condition, not a consequence of behaviour<\/td><\/tr>\r\n        <\/tbody>\r\n      <\/table>\r\n    <\/div>\r\n    <p class=\"cslac-tnote\">Indicative, educational information. The assessment of your particular case is the responsibility of a professional with experience in lipedema.<\/p>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= OBESITY ============================= -->\r\n<section class=\"cslac-section dark\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-prose\">\r\n      <div class=\"cslac-eyebrow\">The costliest confusion<\/div>\r\n      <h2>Does obesity <span>cause<\/span> lipedema?<\/h2>\r\n      <p>\r\n        No. They are different entities, even though they can coexist and be confused, and that confusion is what leaves many women with the wrong diagnosis for years.\r\n      <\/p>\r\n      <p>\r\n        It is the situation we describe in <a class=\"cslac-link\" href=\"\/en\/why-fat-legs-thin-body\/\">why I have fat legs and a thin body<\/a>. The practical difference lies in the pattern: obesity distributes fat <strong>generally<\/strong> and responds to a calorie deficit; lipedema builds up <strong>symmetrically in the legs or arms<\/strong>, spares the hands and feet, <strong>hurts<\/strong> and barely responds to diet. You can have lipedema at a normal weight, and you can have obesity without lipedema.\r\n      <\/p>\r\n      <p>\r\n        That is why <a class=\"cslac-link\" href=\"\/en\/lipedema-bmi-calculator\/\">BMI has limited value<\/a> in lipedema: it can classify as overweight women whose main problem is something else. This table sums up the differences.\r\n      <\/p>\r\n    <\/div>\r\n    <div class=\"cslac-tablewrap\">\r\n      <table class=\"cslac-table\">\r\n        <thead><tr><th>Criterion<\/th><th>Lipedema<\/th><th>Overweight or obesity<\/th><\/tr><\/thead>\r\n        <tbody>\r\n          <tr><td>Fat distribution<\/td><td>Localised in the legs and\/or arms<\/td><td>Generalised, including the trunk<\/td><\/tr>\r\n          <tr><td>Symmetry<\/td><td>Symmetrical on both sides<\/td><td>Not a defining feature<\/td><\/tr>\r\n          <tr><td>Hands and feet<\/td><td>Spared, with a step at the ankle or wrist<\/td><td>Affected like the rest of the body<\/td><\/tr>\r\n          <tr><td>Pain on touch<\/td><td>Frequent, on pressure<\/td><td>Usually painless<\/td><\/tr>\r\n          <tr><td>Easy bruising<\/td><td>Frequently reported by patients, although not a diagnostic criterion on its own<\/td><td>Not characteristic<\/td><\/tr>\r\n          <tr><td>Response to diet and exercise<\/td><td>Poor in the affected areas<\/td><td>Responds to a calorie deficit<\/td><\/tr>\r\n          <tr><td>Family history<\/td><td>Frequent, with the same pattern<\/td><td>Relevant, but without that localised pattern<\/td><\/tr>\r\n        <\/tbody>\r\n      <\/table>\r\n    <\/div>\r\n    <div class=\"cslac-prose\">\r\n      <div class=\"cslac-actions\" style=\"justify-content:flex-start;margin-top:28px;\">\r\n        <a href=\"#contacto_footer\" class=\"cslac-btn-primary\">Request a concierge assessment<\/a>\r\n        <a href=\"\/en\/lipedema-test\/\" class=\"cslac-btn-secondary\">Take the lipedema test<\/a>\r\n      <\/div>\r\n    <\/div>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= WHAT TO DO ============================= -->\r\n<section class=\"cslac-section white\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-prose\">\r\n      <div class=\"cslac-eyebrow\">The next step<\/div>\r\n      <h2>What to do if this sounds like you<\/h2>\r\n      <p>\r\n        Understanding the causes is useful above all for two things: to stop looking for blame where there is none, and to know there is a way forward. If the pattern we describe feels familiar, this is the logical order:\r\n      <\/p>\r\n      <ul>\r\n        <li><strong>Confirm the suspicion:<\/strong> go through the <a class=\"cslac-link\" href=\"\/en\/lipedema-symptoms\/\">symptoms of lipedema<\/a> and take the <a class=\"cslac-link\" href=\"\/en\/lipedema-test\/\">indicative test<\/a>.<\/li>\r\n        <li><strong>Place your case:<\/strong> look at the <a class=\"cslac-link\" href=\"\/en\/stages-of-lipedema\/\">stages and types<\/a> to understand the terms used in consultation.<\/li>\r\n        <li><strong>Seek a diagnosis:<\/strong> it is clinical and made by an experienced professional. See the <a class=\"cslac-link\" href=\"\/en\/lipedema-diagnosis\/\">lipedema diagnosis<\/a>.<\/li>\r\n        <li><strong>Learn the options:<\/strong> from conservative management to surgery when indicated, in the <a class=\"cslac-link\" href=\"\/en\/lipedema-treatment\/\">integrated treatment<\/a>.<\/li>\r\n      <\/ul>\r\n      <p>\r\n        Lipedema is a chronic condition and has no cure, but knowing what you have changes the approach completely: you go from trying to fix something that does not depend on you, to treating a condition with medical criteria.\r\n      <\/p>\r\n    <\/div>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= FAQ ============================= -->\r\n<section class=\"cslac-section\">\r\n  <div class=\"cslac-container\">\r\n    <div class=\"cslac-lead\"><div class=\"cslac-eyebrow\">Frequently asked questions<\/div><h2>Questions about the causes of lipedema<\/h2><\/div>\r\n    <div class=\"cslac-faq\"><div class=\"cslac-faq-item\"><h3>What causes lipedema?<\/h3><p>The exact cause is not known. It is considered a multifactorial condition in which a genetic predisposition and hormonal changes play the main roles, alongside changes in the fat tissue, the microcirculation and the lymphatic system.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Is lipedema hereditary?<\/h3><p>There is a clear hereditary component: it is common to find the same pattern in a mother, grandmother or sisters. No single responsible gene has been identified, and inheriting the predisposition does not necessarily mean developing the condition.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Does lipedema appear because of a poor diet?<\/h3><p>No. Diet does not cause lipedema, and lipedema tissue responds far less to a calorie deficit than ordinary fat. Gaining weight can, however, make the symptoms worse.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Why does lipedema affect almost only women?<\/h3><p>Because of the weight of the hormonal component: it appears or worsens at stages such as puberty, pregnancy and menopause. It is very rare in men.<\/p><\/div><div class=\"cslac-faq-item\"><h3>At what age does lipedema appear?<\/h3><p>There is no single age, but the first sign most often appears at puberty and in adolescence. From then on, pregnancy and menopause are the moments when it tends to become most apparent or worsen.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Is lipedema linked to PCOS or endometriosis?<\/h3><p>Some patients with lipedema also have polycystic ovary syndrome or endometriosis, both hormone-sensitive conditions. Occurring together does not mean one causes the other, but it is useful information when assessing the case as a whole.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Can lipedema appear during pregnancy?<\/h3><p>Yes. Pregnancy is one of the moments that most often triggers the onset or accentuates existing lipedema, because of the associated hormonal changes.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Does the contraceptive pill cause lipedema?<\/h3><p>It cannot be said that it causes it. Some patients link the onset or worsening to changes in their hormonal treatment, so it is useful information to mention in consultation.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Which specialist treats lipedema?<\/h3><p>Diagnosis and management are led by a team with specific experience in lipedema. In our case that combines plastic surgery and vascular assessment; depending on the case, physiotherapy, endocrinology or nutrition may be added. Meet the <a href=\"\/en\/medical-team\/\">medical team<\/a>.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Does obesity cause lipedema?<\/h3><p>No. They are different conditions that can coexist. Obesity distributes fat generally and responds to diet; lipedema is symmetrical in the legs or arms, spares the hands and feet, and hurts.<\/p><\/div><div class=\"cslac-faq-item\"><h3>Can lipedema be prevented?<\/h3><p>There is no proven way to prevent it, because the predisposition is genetic. What can be done is to detect it early and manage the factors that worsen the symptoms, such as weight gain.<\/p><\/div><\/div>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= SOURCES ============================= -->\r\n<section class=\"cslac-section white\" style=\"padding-top:0;\">\r\n  <div class=\"cslac-refs\">\r\n    <h3>Sources and references<\/h3>\r\n    <ol>\r\n      <li>Carballeira Bra&ntilde;a A, Poveda Castillo J. <em>The Advanced Care Study: Current Status of Lipedema in Spain, A Descriptive Cross-Sectional Study<\/em>. Int J Environ Res Public Health, 2023;20(17):6647. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/37681787\/\" target=\"_blank\" rel=\"noopener\">View on PubMed<\/a> (study by our team)<\/li>\r\n      <li>S2k guideline Lip&ouml;dem, AWMF 037-012, v5.0 (2024). <a href=\"https:\/\/register.awmf.org\/assets\/guidelines\/037-012l_S2k_Lipoedem_2024-01_01.pdf\" target=\"_blank\" rel=\"noopener\">View guideline<\/a><\/li>\r\n      <li>Herbst KL et al. <em>Standard of care for lipedema in the United States<\/em>. Phlebology, 2021. <a href=\"https:\/\/pubmed.ncbi.nlm.nih.gov\/34049453\/\" target=\"_blank\" rel=\"noopener\">View on PubMed<\/a><\/li>\r\n      <li><em>Hormonal and gynaecological conditions associated with lipedema: a scoping review<\/em>. Biomedicines, 2026;14(1):122.<\/li>\r\n      <li><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK573066\/\" target=\"_blank\" rel=\"noopener\">Lipedema - StatPearls (NCBI)<\/a><\/li>\r\n    <\/ol>\r\n  <\/div>\r\n<\/section>\r\n\r\n<!-- ============================= DISCLAIMER \/ AUTHORSHIP ============================= -->\r\n<section class=\"cslac-section white\" style=\"padding-top:0;\">\r\n  <div class=\"cslac-authorbox\">\r\n    <p><strong>Medically reviewed content.<\/strong> Content produced by the medical team at Lipedema Advanced Care and reviewed by <strong>Dr. Alexo Carballeira Bra&ntilde;a<\/strong>, plastic surgeon (SECPRE-recertified) specialised in the treatment of lipedema, registered with the ICOMV. Meet <a href=\"\/en\/doctor-alexo-carballeira-brana\/\">Dr. Alexo Carballeira<\/a> and the rest of our <a href=\"\/en\/medical-team\/\">medical team<\/a>.<\/p>\r\n    <p>This information is for educational purposes and does not replace a medical consultation or diagnosis. Lipedema is a chronic condition; it has no cure, but its symptoms can be treated. Every case requires an individualised assessment. Last updated: August 2026.<\/p>\r\n  <\/div>\r\n<\/section>\r\n\r\n<section id=\"lac-prefooter-contacto-unico\" class=\"lpf-main-section\">\r\n    <div class=\"lpf-container\">\r\n        <div class=\"lpf-flex-wrapper\">\r\n\r\n            <div class=\"lpf-doctor-side\">\r\n                <div class=\"lpf-doctor-sticky-box\">\r\n                    <img decoding=\"async\" src=\"https:\/\/lipedemaac.com\/wp-content\/uploads\/2026\/03\/dr-alexo-carballeira-consulta-lipedema-marques-del-turia.jpg\" alt=\"Dr. Alexo Carballeira\" class=\"lpf-doctor-img\" title=\"\">\r\n\r\n                    <div class=\"lpf-text-overlay\">\r\n                        <p class=\"lpf-tagline\">PERSONALISED CARE<\/p>\r\n                        <h2 class=\"lpf-hero-title\">\r\n                            Begin your journey to <br>\r\n                            <span class=\"lpf-gold-text\">freedom from lipedema<\/span>\r\n                        <\/h2>\r\n\r\n                        <div class=\"lpf-quote-container\">\r\n                            <p>\"My commitment is to offer you a precise diagnosis and complete support throughout the process.\"<\/p>\r\n                            <span class=\"lpf-signature\">Dr. Alexo Carballeira<\/span>\r\n                        <\/div>\r\n                    <\/div>\r\n                <\/div>\r\n            <\/div>\r\n\r\n            <div class=\"lpf-form-side\" id=\"contacto_footer\">\r\n                <div class=\"lpf-form-box\">\r\n                    <div class=\"lpf-form-header\">\r\n                        <h3 class=\"lpf-form-main-title\">Request an Assessment<\/h3>\r\n                        <p class=\"lpf-form-subtitle\">SPECIALISED PRELIMINARY ANALYSIS<\/p>\r\n                    <\/div>\r\n\r\n                    <div class=\"lpf-form-engine\">\r\n                        <div class=\"wpforms-container wpforms-container-full\" id=\"wpforms-3655\"><form id=\"wpforms-form-3655\" class=\"wpforms-validate wpforms-form\" 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\"description\": \"Why lipedema appears: the role of genetics and hormones, why it affects almost only women and why it is not caused by diet or a lack of exercise.\",\r\n      \"inLanguage\": \"en\",\r\n      \"lastReviewed\": \"2026-08-06\",\r\n      \"dateModified\": \"2026-08-06T10:20:53+00:00\",\r\n      \"about\": { \"@type\": \"MedicalCondition\", \"name\": \"Lipedema\" },\r\n      \"specialty\": { \"@type\": \"MedicalSpecialty\", \"name\": \"Plastic Surgery\" },\r\n      \"isPartOf\": { \"@type\": \"WebSite\", \"name\": \"Lipedema Advanced Care\", \"url\": \"https:\/\/lipedemaac.com\/\" },\r\n      \"author\": { \"@type\": \"Physician\", \"name\": \"Dr. Alexo Carballeira Bra\\u00f1a\", \"medicalSpecialty\": \"PlasticSurgery\", \"url\": \"https:\/\/lipedemaac.com\/en\/doctor-alexo-carballeira-brana\/\" },\r\n      \"reviewedBy\": { \"@type\": \"Physician\", \"name\": \"Dr. Alexo Carballeira Bra\\u00f1a\", \"medicalSpecialty\": \"PlasticSurgery\", \"url\": 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It is considered a multifactorial condition in which a genetic predisposition and hormonal changes play the main roles, alongside changes in the fat tissue, the microcirculation and the lymphatic system.\" } },{ \"@type\": \"Question\", \"name\": \"Is lipedema hereditary?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"There is a clear hereditary component: it is common to find the same pattern in a mother, grandmother or sisters. No single responsible gene has been identified, and inheriting the predisposition does not necessarily mean developing the condition.\" } },{ \"@type\": \"Question\", \"name\": \"Does lipedema appear because of a poor diet?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"No. Diet does not cause lipedema, and lipedema tissue responds far less to a calorie deficit than ordinary fat. Gaining weight can, however, make the symptoms worse.\" } },{ \"@type\": \"Question\", \"name\": \"Why does lipedema affect almost only women?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"Because of the weight of the hormonal component: it appears or worsens at stages such as puberty, pregnancy and menopause. It is very rare in men.\" } },{ \"@type\": \"Question\", \"name\": \"At what age does lipedema appear?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"There is no single age, but the first sign most often appears at puberty and in adolescence. From then on, pregnancy and menopause are the moments when it tends to become most apparent or worsen.\" } },{ \"@type\": \"Question\", \"name\": \"Is lipedema linked to PCOS or endometriosis?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"Some patients with lipedema also have polycystic ovary syndrome or endometriosis, both hormone-sensitive conditions. Occurring together does not mean one causes the other, but it is useful information when assessing the case as a whole.\" } },{ \"@type\": \"Question\", \"name\": \"Can lipedema appear during pregnancy?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"Yes. Pregnancy is one of the moments that most often triggers the onset or accentuates existing lipedema, because of the associated hormonal changes.\" } },{ \"@type\": \"Question\", \"name\": \"Does the contraceptive pill cause lipedema?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"It cannot be said that it causes it. Some patients link the onset or worsening to changes in their hormonal treatment, so it is useful information to mention in consultation.\" } },{ \"@type\": \"Question\", \"name\": \"Which specialist treats lipedema?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"Diagnosis and management are led by a team with specific experience in lipedema. In our case that combines plastic surgery and vascular assessment; depending on the case, physiotherapy, endocrinology or nutrition may be added. Meet the medical team.\" } },{ \"@type\": \"Question\", \"name\": \"Does obesity cause lipedema?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"No. They are different conditions that can coexist. Obesity distributes fat generally and responds to diet; lipedema is symmetrical in the legs or arms, spares the hands and feet, and hurts.\" } },{ \"@type\": \"Question\", \"name\": \"Can lipedema be prevented?\", \"acceptedAnswer\": { \"@type\": \"Answer\", \"text\": \"There is no proven way to prevent it, because the predisposition is genetic. What can be done is to detect it early and manage the factors that worsen the symptoms, such as weight gain.\" } }]\r\n    }\r\n  ]\r\n}\r\n<\/script>\r\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>Causes of lipedema Causes of lipedema:why it appears The exact cause of lipedema is still unknown, but we do know a good deal about what influences it: there is a clear genetic component and a close relationship with hormones, which explains why it almost always appears in women and at specific moments in life. And [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"elementor_header_footer","meta":{"footnotes":""},"class_list":["post-3712","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/pages\/3712","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/comments?post=3712"}],"version-history":[{"count":8,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/pages\/3712\/revisions"}],"predecessor-version":[{"id":6660,"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/pages\/3712\/revisions\/6660"}],"wp:attachment":[{"href":"https:\/\/lipedemaac.com\/en\/wp-json\/wp\/v2\/media?parent=3712"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}